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為促進骨科學術交流和技術創新，汕頭大學醫學院第一附屬醫院中德骨科交流中心於2024年11月29日邀請柏林夏洛特大學綜合醫院Julius Wolff研究所創始主任、哈佛大學Wyss生物啟發工程研究所國際學者Georg Duda教授進行主題演講（線上），汕頭大學醫學院附屬第一醫院骨科胡軍教授致辭並主持會議。Duda教授以“影響骨愈合的生物和物理因素”為(wei)題(ti)，深(shen)入(ru)探(tan)討(tao)骨(gu)再(zai)生(sheng)治(zhi)療(liao)的(de)難(nan)點(dian)與(yu)新(xin)進(jin)展(zhan)。其(qi)領(ling)導(dao)的(de)團(tuan)隊(dui)聚(ju)焦(jiao)骨(gu)愈(yu)合(he)早(zao)期(qi)階(jie)段(duan)，發(fa)現(xian)骨(gu)折(zhe)斷(duan)麵(mian)形(xing)成(cheng)血(xue)腫(zhong)後(hou)會(hui)出(chu)現(xian)係(xi)列(lie)炎(yan)性(xing)反(fan)應(ying)，若(ruo)炎(yan)性(xing)無(wu)法(fa)正(zheng)常(chang)消(xiao)退(tui)，會(hui)阻(zu)礙(ai)骨(gu)再(zai)生(sheng)。通(tong)過(guo)對(dui)大(da)數(shu)據(ju)的(de)研(yan)究(jiu)，他(ta)們(men)發(fa)現(xian)CD8+TEMRAxibaoshiguanjianganraoyinzi，bingchangshishiyongyaowujianshaoqiyingxiang，xianzhugaishanguyuhexiaoguo。ciwai，tuanduiyanjiujieshilexueguanshengchengquexianyeshiguyuheshibaidezhongyaoyuanyin，faxiangudingfangshiduixueguanshengchengyouzhongyaoyingxiang。ciwai，Duda教授還分享了3D生物打印技術的進展，利用HUVEC和hMSC細xi胞bao優you化hua了le微wei血xue管guan網wang絡luo打da印yin材cai料liao，並bing介jie紹shao了le新xin型xing粘zhan彈dan性xing骨gu替ti代dai支zhi架jia。這zhe種zhong載zai體ti具ju有you優you異yi的de應ying力li鬆song弛chi性xing能neng，能neng夠gou顯xian著zhu提ti升sheng骨gu再zai生sheng效xiao率lv，目mu前qian正zheng進jin行xing臨lin床chuang試shi驗yan。此ci外wai，本ben次ci會hui議yi還hai邀yao請qing了le許xu建jian坤kun教jiao授shou進jin行xing題ti為wei“骨科中以鎂元素植入物在臨床使用的科研基礎”的de演yan講jiang。許xu建jian坤kun教jiao授shou介jie紹shao道dao，鎂mei基ji可ke降jiang解jie金jin屬shu在zai骨gu科ke中zhong的de應ying用yong因yin其qi生sheng物wu相xiang容rong性xing和he成cheng骨gu活huo性xing日ri漸jian受shou到dao關guan注zhu。其qi團tuan隊dui長chang期qi研yan究jiu表biao明ming，鎂mei在zai降jiang解jie過guo程cheng中zhong釋shi放fang鎂mei離li子zi和he氫qing氣qi，能neng調tiao節jie骨gu組zu織zhi細xi胞bao、感知神經和骨膜幹細胞的功能。鎂離子通過刺激感覺神經釋放降鈣素基因相關肽（CGRP），促cu進jin成cheng骨gu細xi胞bao分fen化hua，加jia速su骨gu折zhe愈yu合he，並bing顯xian著zhu減jian少shao骨gu纖xian維wei化hua，此ci外wai，鎂mei的de局ju部bu釋shi放fang和he免mian疫yi調tiao節jie機ji製zhi同tong樣yang對dui骨gu愈yu合he過guo程cheng發fa揮hui重zhong要yao作zuo用yong。該gai研yan究jiu能neng夠gou為wei骨gu質zhi疏shu鬆song性xing骨gu折zhe等deng複fu雜za骨gu病bing治zhi療liao提ti供gong新xin策ce略lve，並bing推tui動dong了le鎂mei材cai料liao的de臨lin床chuang轉zhuan化hua。會hui議yi期qi間jian，在zai場chang的de年nian輕qing醫yi生sheng及ji研yan究jiu生sheng積ji極ji發fa問wen，與yu兩liang位wei講jiang者zhe進jin行xing深shen入ru的de探tan討tao，獲huo取qu了le寶bao貴gui的de建jian議yi。視shi頻pin會hui議yi結jie束shu之zhi際ji，胡hu軍jun教jiao授shou致zhi謝xieDudajiaoshoujixujiankunjiaoshoudejingcaixueshufenxiang，bingbiaoshiqidaiweilaishuangfangnengkaizhangengjiashenrudexueshujiaoliuyuhezuo。bencixueshuhuiyikaikuoguojishiye，weigukexuekejianshezhurulexinsilu、新動力。汕頭大學醫學院第一附屬醫院骨科將繼續推動學術國際化發展，促進骨科創新研究及生物材料轉化應用。
To promote academic exchanges and technical innovation of orthopedics, the Sino-German Communication Center for Orthopedics of the First Affiliated Hospital of Shantou University Medical College invited Prof. Georg Duda, Director of Julius Wolff Institute of Charité–University Medicine Berlin and International Faculty Member of the Wyss Institute for Biologically Inspired Engineering of Harvard University, to give a special lecture online on November 29th, 2024.Prof. HU Jun from the Department of Orthopedics of the First Affiliated Hospital of Shantou University Medical College addressed a welcome speech and moderated the webinar. Prof. Duda gave an in-depth talk entitled "How Biological and Physical Factors Affect Bone Healing" on the difficulties and new improvement of bone regeneration therapy. His team focused on the first two stages of bone healing process, and found that if disorders in the downregulation of inflammation happen after hematoma forms at the surface of fracture, there will be problems in bone healing. With the study on big data, the team proved that CD8+TEMRA cell is a key factor to interfere bone healing. So they did drug trials to reduce these cells so as to improve bone healing. Meanwhile, Prof. Duda's team also discovered from research that the impairment in angiogenesis is also a key reason for bone healing failure, and that rigid and semi-rigid fixation lead to different result of angiogenesis. Moreover, Prof. Duda shared the progress of 3D bio-printing technology of printing vessels with HUVECs and hMSCs to form highly-organized microvascular structures. And he also introduced a new viscoelastic bone fracture scaffold. This kind of scaffold with lower stiffness can efficiently improve bone formation in the scaffold and is now under clinical trials. Following that, this webinar also invited Prof. XU Jiankun to give a lecture on "Scientific Foundation for the Application of Magnesium-based Devices in Orthopedics". According to Prof. XU Jiankun, the application of magnesium-based biodegradable metal in orthopedics is attracting more and more attention due to its properties. According to long-term research, magnesium releases magnesium ions and hydrogen and can regulate the function of cells in the bone, sensory neurons and periosteum-derived stem cells (PDSCs).Magnesium ions can stimulate sensory neurons to release CGRP which has influence on differentiation of PDSCs and accelerates bone healing. And magnesium-based biodegradable metals can also reduce fibrosis significantly. In addition, magnesium's local release and immunomodulatory effects also play key roles in bone healing process. This research will provide novel strategies for treating complex bone diseases, such as osteoporotic fractures, and promote the clinical application of magnesium-based materials. During the webinar, the young surgeons and postgraduates onsite were active in raising questions and having in-depth discussions with the two professors, obtaining valuable advice. At the end of the webinar, Prof. HU Jun thanked Prof. Duda and Prof. XU Jiankun for their wonderful academic sharing and looked forward to deeper academic exchanges and cooperation between both sides. This academic conference broadened the international vision and injected new ideas and new inspirations for the construction of orthopedic specialty. The Department of Orthopedics of the First Affiliated Hospital of Shantou University Medical College will continuously promote its academic development at an international stage, innovative research in orthopaedics and translational application of biomaterials.
